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DISCUSSION In this study, 7.5 mg of tirzepatide did not produce significant improvements in glycemic control or body weight after switching from 1.0 mg of semaglutide, while the 10 mg dose resulted in significant HbA1c reduction, but not significant weight loss

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An increase in the Akkermansia spp

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Although current evidence supports broad applicability across BMI, diabetes status, and fibrosis stages F2-F3, subgroup analyses suggest attenuated responses in non-obese patients and in certain ethnic groups (Hispanic patients in ESSENCE), emphasizing the need for precision medicine approaches incorporating anthropometric, genetic (e.g., PNPLA3, HSD17B13), and metabolic profiling