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These pathological changes result in mucus layer thinning and elevated permeability, substantially compromising barrier function and increasing intestinal epithelial vulnerability to pathogenic invasion and harmful stimuli [37]

Medication changes depend on your medical history, side effects, weight loss progress, symptoms and overall health goals

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However, our rigorous matching procedures with the intention to achieve a greater level of between-group comparability on a wide range of baseline patient characteristics (i.e., prior GLA exposure history, comorbidities, diabetes severity, and co-medications) and the regression analyses with adjustment for imbalanced baseline characteristics may have minimized this concern

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Therefore, the change in BP was inverted as the BP of the placebo group increased after randomization