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The mean percentage weight reduction in the retatrutide groups at 48 weeks were 8.7%, 17.1%, 22.8%, and 24.2% for the groups treated with 1 mg, combined 4 mg, combined 8, and 12 mg, respectively

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Rubino et al., Diabetes, Obesity and Metabolism 2025 meta-analysis of GI tolerability across SURMOUNT-1 to -4

The injection day and time of day are less critical for the medication itself compared to shorter-acting options