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The following points identify what shapes outcomes for most users: Genetics: Genes play a role in how the body stores fat, responds to hunger cues, and manages hormones

Many patients on tirzepatide or semaglutide experience energy dips , particularly during the first few weeks when their body is adjusting to reduced caloric intake

Efficacy and safety of HRS9531, a novel dual GLP-1/GIP receptor agonist, in obese adults: a phase 2 trial

In a 48-week clinical trial, higher doses consistently led to greater average weight loss: Weight loss by dose (48-week clinical trial) In this trial, at the highest dose (12 mg), people lost an average 24% of their starting weight on average

Clinical trials have shown weight loss effects within the first month, with more significant results emerging over several months of consistent use

The manufacturer study Eli Lilly conducted a study involving 11 lactating women who received a single 5 mg subcutaneous dose of tirzepatide