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In the ongoing SURPASS-CVOT trial (ClinicalTrials.gov ID NCT04255433), the safety of tirzepatide versus GLP-1RA dulaglutide is assessed in patients living with T2DM with confirmed atherosclerotic CVD, including participants treated with insulin and SGLT2 inhibitors, where the composite primary outcome will be the time to first occurrence of MACE

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2 Data show that more than 50% of patients started on monotherapy will require a second medication to control diabetes after three years