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Funding The work was supported by the: Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) (2025MSXM106), the Chongqing Municipal Health Commission (no

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Wegovy acts on GLP-1 receptors primarily in the pancreas, brain, and gastrointestinal tract, while ibuprofen exerts its effects through COX enzyme inhibition affecting prostaglandin synthesis throughout the body

The assumption was that more receptor activation would mean more side effects