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Patients showed an average reduction of 13.7% of body weight with semaglutide

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3.3 Advanced age and DIO each induce transcriptional changes within the tumor related to cellular proliferation, epithelial mesenchymal transition, and angiogenesis Tumors from aged control and young DIO mice, relative to young control mice, were enriched for gene sets that reflect processes linked to tumor progression including cellular proliferation (e.g., mitotic spindle and E2F targets), epithelial mesenchymal transition, and angiogenesis, among others ( Supplementary Figure 1D )

Some protocols suggest increasing by 1.25 mg when side effects are a concern, and at 5 mg/mL, that 1.25 mg increase is a clean 25-unit adjustment