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The question of whether tirzepatide causes bone loss is actively being studied

Sujith Ramachandran is an Associate Professor of Pharmacy Administration, University of Mississippi Liang-Yuan (Claire) Lin PhD Candidate in Pharmacy Administration, University of Mississippi This article was originally published in The Conversation
A comprehensive 2017 review by Peyrol et al

doi: 10.1172/JCI167700
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12 These effects could be secondary to reduced hepatic lipogenesis, increased fatty acid oxidation and modulation of lipoprotein metabolism