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Its active ingredient, semaglutide, has been shown to reduce appetite and food intake, which can lead to significant weight loss in individuals with obesity or overweight when coupled with diet and exercise

Any alternative that produces significant weight loss, whether pharmaceutical or otherwise, carries a similar risk of telogen effluvium (temporary, diffuse hair shedding)

Smith, J.A., Williams, R.B., and Thompson, K.L

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The cardiovascular risk profile of the average participant at week 24 looks meaningfully better than it did at week zero, independent of the weight loss itself