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The case is strong and getting stronger

Conclusions/interpretation Progression to diabetes explained less than one-quarter of the risks of clinical outcomes associated with prediabetes

Identification of genetic variants associated with the efficacy and side effects of GLP1 medications could underpin development of precision medicine approaches in the treatment of obesity.

In islet alpha cells, GLP-1(936) led to inhibition of Ca2+ entry via voltage-gated Ca2+ channels sensitive to -agatoxin, with consequential pertussis-toxin-sensitive depletion of the docked pool of secretory granules, effects that were prevented by the glucagon receptor antagonists REMD2.59 and L-168049

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