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Furthermore, the companys development pipeline, including a large Phase 2 basket trial enrolling patients with various rare genetic disorders of obesity, incorporates MC4R -deficient patients as just one of several cohorts [58]

doi: 10.1152/ajpgi.90635.2008

A recent study further demonstrated that the suppression of hepatic glucose production, measured via the clamp technique using tracer glucose, was accompanied by a reduction in glucagon levels and increased insulin secretion in subjects with type 2 diabetes administered 100 mg of vildagliptin (55)

Whether this translates to humans is unresolved, so the label contraindicates it in the highest-risk groups as a precaution

But they often drink less too, and this gets overlooked

The pharmaceutical chemical maker Cambrex, for example, says it has no such plans