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These effects are typically most noticeable when starting treatment or increasing doses and generally diminish over time as your body adjusts

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Tirzepatide and breastfeeding do not mix, and anyone who becomes pregnant on tirzepatide needs to discontinue immediately under medical supervision

Weight loss is gradual on purpose, which helps protect muscle and support long-term results

A recent systematic review further underscores that maintenance is facilitated not only by these concrete selfregulatory behaviors but also by broader psychosocial processes, including adaptive coping, ongoing social support, and the integration of healthy routines into everyday life [79]

Disappointingly, the data presented at CTAD showed that semaglutide did not demonstrate a statistically significant slowing of disease progression compared with placebo on the CDR-SB primary endpoint in either trial