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Otherwise, patients taking both a DPP4i and GLP1-RA could benefit from discontinuing the DPP4i

Abstract Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been pivotal for obesity treatment, achieving 1525 % weight loss over 1224 months, but questions remain about the potential influence of concomitant losses in muscle mass

Key Safety Considerations The safety of GLP-1 receptor agonists in older adults is a nuanced question that depends on individual patient characteristics, comorbidities, and careful clinical assessment

Your AID algorithm will need time to adapt to the new patterns, and your basal and bolus settings will likely need recalibration

Additional Factors in Long Term Outcomes Exercise could play a key role in weight maintenance A study examining long-term weight loss maintenance after stopping liraglutide therapy found that combining medication with supervised exercise led to significantly better outcomes compared to using GLP-1s alone or a placebo

Total daily intake matters more than per-meal distribution, and training matters more than either