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Among the observational studies 39,45,46,49,50,51 comprised by the meta-analyses, two are worth a separate mention

Obesity induces metabolic disturbances in adipose tissue, influencing the release of hormones, adipokines, inflammatory cytokines, growth factors, enzymes, and free fatty acids [12]

Activated microglia in patients with AD release proinflammatory factors, which further promote ROS production, creating a vicious cycle of neuroinflammation and mitochondrial dysfunction (Qian et al., 2025)

The next week I also mentioned GLP-1s to my ob-gyn, who was even more on board

Yes, rapid initial weight loss often correlates with a greater initial metabolic shift, making the subsequent Metabolic Adaptation phase potentially more challenging to overcome effectively

However, these reports are not scientifically validated and cannot establish a causal relationship