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After comparing the shape, quantity and area of islets, that there was no significant difference in these indicators between groups (Figure 2B)

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This structural parallelism makes them excellent companion reference compounds in preclinical research because many physicochemical properties such as solubility, albumin binding, and subcutaneous depot behavior are comparable, isolating receptor pharmacology as the primary experimental variable

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Over-interpretation of secondary outcomes may lead to spurious inferences, underscoring the need for caution when translating these findings into clinical reassurance.This aligns with emerging data linking metabolic improvements such as weight loss, insulin sensitivity, and reduced inflammation to decreased malignancy risk in high-risk populations with type 2 diabetes or obesity (Marso et al., 2016a

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