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In real-world settings, additional causes of discontinuation include high out-of-pocket costs, restrictive insurance coverage, prior authorization requirements, and drug shortages [52]
The selection of AC16 cells (18) is attributed to their shared characteristics with primary cardiomyocytes, such as the expression of cardiac-specific markers (16,19,20) and responsiveness to H/R conditions (21), making them a valuable tool for exploring the mechanisms of heart diseases
Hydration is also important for mitigating unwanted side effects
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