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And the dose equivalencies are not straightforward because you cannot simply convert milligrams between two medications that work through different receptor profiles

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Therefore, SSRIs should be considered pharmacologically heterogeneous agents whose selection requires attention to binding profiles, patient comorbidities, genetic/epigenetic moderators, and long-term monitoring priorities [21-27,37]

(4) Co-administration with drugs highly dependent on CYP3A for clearance and for which elevated concentrations are associated with serious and/or life-threatening reactions
[DOI] [PMC free article] [PubMed] [Google Scholar] 946.Hornigold D.C., Roth E., Howard V., Will S., Oldham S., Coghlan M.P
