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In SOD (G93A) ALS mice, a clinically translatable dose of exendin-4 as well as an intracerebroventricular injection of GLP-1secreting mesenchymal stromal cells improved motor function and preserved spinal motor neurons, accompanied by reduced glial activation (167)

Domperidone is a type II dopamine antagonist similar to metoclopramide, and is equally efficacious but with lower central side effects

Lancet 2019;394:12130.PubMed 71

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Enhances Insulin Sensitivity: GLP-1 improves insulin sensitivity, particularly in muscle tissue, allowing cells to utilize glucose more efficiently for energy rather than storing it as fat