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Too much fat can feel heavy for some people on GLP-1 days

Although neither the DSM nor the International Classification of Diseases (ICD) formally recognizes addiction to highly palatable foods as a clinical diagnosis (LaFata et al., 2025), there is nevertheless a notable parallel between substance use disorders and certain patterns of eating behavior

Guarnotta V, Bianco MJ, Vigneri E, Panto F, Lo Sasso B, Ciaccio M, et al

Affected tissues include skeletal muscle, myocardium, and brown adipose tissue

Pathways for Intracellular Signaling in the Langerhans Islets GLP- 1 receptor, GIP receptor, and glucagon receptor are mainly expressed on beta, alpha, and delta cells in the islets of Langerhans, where they influence hormone secretion and regulate the survival and proliferation of endocrine cells

Tracking liver enzymes alongside metabolic markers like HbA1c and lipids gives you a complete picture