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Whilst these medications work primarily by regulating blood glucose and appetite, emerging interest surrounds their potential effects on mental health

Liu Y, Zhao J, Guo W

Separately, GLP-1 RA pretreatment in Abeta142-treated hippocampal primary cell cultures significantly increased phosphorylated CaMKII alpha -positive cells indicating that GLP-1 RAs may have neuroprotective effects through glutamate receptor-mediated responses.Reference Wang, Wang, Jiang, Yuan, Yu and Li 46 Taken together, GLP-1 RAs may have protective effects against neuropathological changes by promoting neurogenesis and synaptic plasticity

This finding is consistent with the hypothesis that incretin signalling at GLP-1R and GIPR functionally counterbalances the glucagonergic input under high-glucose conditions

The sample was mixed overnight at 4 C
