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Nevertheless, increasing proof indicates that metformin primarily acts on the gastrointestinal system

The first type, such as short-chain fatty acids and 2-oleoyl glycerol (2-OG, derived from dietary fats), is produced by intestinal microorganisms directly digesting or fermenting food components

IR is frequently accompanied by chronic, low-grade systemic inflammation, driven by elevated concentrations of pro-inflammatory cytokines such as TNF-, IL-6, and IL-1, produced by adipose tissue and immune cells in the context of metabolic dysfunction [6,7]

[1] [3] Dizziness is a recognised adverse reaction in the Summary of Product Characteristics (SmPCs) for several GLP-1 medications, though the frequency varies between different products

Arthritis burden report

Heres a brief rundown of what some of those look like