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By payor, prescriptions per enrollee-member increased fastest for Medicare, as volume grew three times faster than enrollment as members were using more prescriptions about 35 per enrollee in 2023

Divergence across payer type matters: Commercial patients adopt GLP1s earlier and often remain on monotherapy, while Medicare patients face stricter controls and higher comorbidity burdens

Blockade of the GLP-1 receptor and subdiaphragmatic vagal transmission rescued the deficient locomotor phenotype in ABX-treated mice