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Addressing comorbidities strengthens weight-loss outcomes

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Published Phase 2 data shows discontinuation rates of 5-8% across active treatment groups comparable to semaglutide (STEP trials: ~7%) and tirzepatide (SURMOUNT trials: ~6-7%)

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Consequently, dual GLP-1/glucagon agonists survodutide, and triple GLP-1/GIP/glucagon agonists retatrutide are not spared gastrointestinal adverse events, as glucagon related pro-emetic signaling may offset any potential tolerability benefits from GIP agonism ( The contribution of amylin-based therapies to gastrointestinal adverse events remains less clear
