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Description
These medications stop glucagon from being released by alpha cells, which helps prevent the liver from producing too much glucose

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Do not do this while on semaglutide

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The pancreas and central nervous system, specifically hypothalamic structures, have been shown to robustly and directly respond to GLP-1R agonism, mediating anti-diabetic and anti-obesogenic physiology and behaviors, respectively
It is similar to having a car with a V12 engine, but without any fuel available for it to run
