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A separate 2025 trial in NEJM Evidence (Shah et al.) in adults with T1D and obesity on AID found that around one in three semaglutide-treated participants met a combined goal of improved time in range, low hypoglycemia, and at least 5% weight loss

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I tried it for a bit and then what I realized was I was like, Oh no, nothing about my eating has anything to do with being hungry. All this does is make you feel not hungry." Kandi Burruss The former Xscape member revealed that she tried a weight-loss drug on the Virtual Reali-Tea podcast in June

That is one reason the semaglutide vs tirzepatide weight loss question should not be reduced to a social media debate

These include type 2 diabetes and prediabetes (because GLP-1 medications affect blood sugar), thyroid conditions (because of the boxed warning about medullary thyroid carcinoma), a history of pancreatitis (because GLP-1 medications carry a small risk of pancreatitis), gastroparesis or other gastric motility disorders (because GLP-1 medications slow gastric emptying), and any history of eating disorders (because the appetite-suppressing effects of GLP-1 medications require careful management in patients with disordered eating)