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Furthermore, the SGLT2-i hybrid diuretic effect, which combines natriuresis and osmotic diuresis, might also have cardioprotective properties leading to preload and myocardial stretch reduction (the diuretic hypothesis) (51)

The angiotensin-converting enzyme (ACE), secreted by lung and kidney, converts ANG I to ANG II, whereas the angiotensin-converting enzyme 2 (ACE2) further cleaves ANG II to ANG (1,7)

Digestion Changes: By slowing down digestion, GLP-1 RAs may affect how well your body absorbs some vitamins and minerals

Nearly two thirds of patients discontinue treatment before reaching the 12-week mark needed for meaningful weight loss

The evidence reveals significant heterogeneity in the effects of GLP-1RAs across different cancer types

TABLE 2 outlines a practical approach based on the Three Es method that pharmacists can use to systematically educate patients and manage GI AEs associated with GLP-1 RA therapy