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The randomized, double-blind trial found that daily supplementation with pasteurized Akkermansia muciniphila for three months resulted in reduced insulin resistance, decreased plasma total cholesterol, and modest improvements in body weight and fat mass compared to placebo

Although these drugs are FDA-approved to treat specific conditions, such as obesity or type 2 diabetes, research studies for potential additional uses and conditions, beyond obesity and diabetes, are underway

The GLP-1 System: Physiology, Receptors, and CNS Distribution 2.1

[DOI] [PMC free article] [PubMed] [Google Scholar] 571.Herzberg-Schafer S., Heni M., Stefan N., Haring H.U., Fritsche A

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The system is overprotective by evolutionary design -- the cost of failing to detect a poison is death, while accidentally rejecting a safe but bitter food just means eating slightly less, which isn't serious