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The mechanism makes physiological sense

Hypoglycemia (RR 353, 95% CI 199 to 627) and total adverse reactions (RR 114, 95% CI 110 to 119) occurred more frequently in the daily group than that in the weekly group ( Table S19 )

Ozempic hair loss does not appear as an official side effect, but shedding can occur during steep calorie deficits

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Retinal experts do recommend obtaining a baseline eye exam and considering closer follow-up of patients on GLP-1RAs within the first 12 to 18 months of starting the drug, particularly for those who have more severe DR at baseline, high baseline HbA 1c percentage, and rapid improvement in glycemic control similar to the characteristics of the patients enrolled in SUSTAIN 6

The glucagon-like peptide-1 receptor (GLP-1R) is ubiquitously present across multiple bodily tissues, including the pancreas, lungs, kidneys, central nervous system, cardiovascular system, gastrointestinal tract, as well as skin and vagus nerves (its tissue distribution is illustrated in Figure 2 ) (97)