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second, the knockdown of SESN2 leads to a reduction in the translocation of p62 to the mitochondria and decreases its phosphorylation level at critical sites (such as Ser403), which is necessary for the encapsulation of the mitochondria by autophagosomes

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Conversely, tremors, heat intolerance, or anxiety may indicate overtreatment, though these are less common during weight loss therapy because improved metabolic health often improves baseline thyroid hormone needs