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Hydrate and Replenish Electrolytes to Combat Semaglutide Fatigue Water helps but if youre also losing fluids from GI side effects, you may need to replace sodium, potassium, and magnesium, too

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Practical management strategies: Eat smaller meals more frequently rather than large meals Avoid high-fat and greasy foods during dose escalation periods Stay well hydrated throughout the day Time your injection when minor nausea will be least disruptive Consider avoiding foods that commonly trigger nausea (spicy, acidic, very sweet) Decreased appetite versus loss of appetite There is an important distinction between healthy appetite suppression and appetite loss that crosses into problematic territory

But clinicians are also noting mood changes, flattened affect, and potential links to depression in patients with dopamine-related vulnerabilities

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Build the nutritional habits, exercise routine, and sleep hygiene that will support you at maintenance from the very beginning