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However, it is plausible that these hereditary genetic variations and epigenetic modifications dictate the baseline reactivity of the cutaneous microenvironment by priming local cell populations, and instigating the complex cellular crosstalk explored in the following section

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De manera directa, se han descrito niveles elevados de ansiedad, depresin y neurosis en pacientes con diabetes, y su relacin con sntomas gastrointestinales ha sido previamente informada, implicando un factor adicional no orgnico de disfuncin gastrointestinal asociado a diabetes34,35

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