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Additionally, it increases sensitivity to leptin, which increases fat burning for an extended period of time and alters natural brain chemistry to reduce appetite

[DOI] [PubMed] [Google Scholar] 73.Tuttle KR, et al

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While there were several possibilities for derivatization toward the C-terminal, as there is already a lysine in position 26 available for chemical derivatization, this was a preferred position for the attachment of a fatty acid

So, I would just recommend talking with your doctor to see maybe which one they are most comfortable prescribing, and then which one insurance is going to potentially cover