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Previous reviews, while exploring the impact of GLP-1RAs on immune and inflammatory diseases, have not established a connection between the regulatory roles of immune cells and the impact of the treatment on disease progression

Common Side Effects of GLP-1 Medications Serious but Rare Side Effects Who Should Use GLP-1 Medications With Caution

Gallstones, which are small, rock-like deposits of hardened digestive fluid, may occur because GLP-1 agonists can delay the emptying of bile from the gallbladder

Notably, while GLP-1 can potentially affect glucagon secretion via its stimulatory effect on the -cells in normal physiological conditions, GLP-1 also inhibits glucagon release in type 1 diabetes, thus demonstrating that GLP-1 inhibition of glucagon secretion does not fully depend on the -cell secretome [516]

Adverse effects such as nausea, vomiting, and gastrointestinal discomfort remain common, but usually diminish with time and proper dose escalation

[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Kreymann B., Williams G., Ghatei M.A., Bloom S.R