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So they developed a small company in California called Amylin Pharmaceuticals, they developed with a bit of help from Eli Lilly, they developed exendin four for diabetes therapy, and it was approved in 2005

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2 Calorie restriction and its effect on anxiety and depression Anxiety and depression are highly comorbid, and a strong predictor of major depressive disorder is comorbid anxiety disorder (36, 37)
Reports indicate it was generally mild and infrequently led to treatment discontinuation

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