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Rare: Potential risk of NAION (as discussed)

Zouboulis, Anti-aging data and support claims-consensus statement

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Can I split my weekly dose into two smaller doses

However, potential adverse mental health effects have also been reported and require vigilance: Nausea and gastrointestinal symptoms , common side effects of GLP-1 medications, may increase anxiety in susceptible individuals Rapid weight loss can occasionally trigger psychological distress or exacerbate eating disorder behaviours Mood changes , including low mood, have been reported in post-marketing surveillance, though causality remains uncertain Some patients report feeling emotionally flat or detached , though this is anecdotal and not well characterised in clinical trials The Summary of Product Characteristics (SmPC) for GLP-1 receptor agonists used for weight management (such as Saxenda and Wegovy) includes specific warnings about monitoring for mood disorders and suicidal thoughts

31,32 Accordingly, a meta-analysis including 68,653 patients from 10 trials showed that GLP-1 RAs reduce HF hospitalisations only in patients without history of previously diagnosed HF