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This clean hepatic safety profile is reassuring and distinguishes orforglipron from the Pfizer candidates that failed in development

[DOI] [PubMed] [Google Scholar] 50.Opazo-Rios L, et al

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Pregnancy and Lactation Contraindications : According to FDA prescribing information: Pregnancy : Contraindicated : Do not use GLP-1 medications if pregnant Discontinuation Timeline : Stop at least 2 months before planned pregnancy (based on medication wash-out period) Rationale : Animal studies showed potential fetal harm

FDA Drug Safety Communication: FDA warns that DPP-4 inhibitors for type 2 diabetes may cause severe joint pain

Simone Wajner, Federal University of Rio Grande do Sul, Brazil
