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Physiological roles of GLP-1 The GLP-1 is a 30-amino acid hormone that works mainly as an incretin in the pancreatic cells, enhancing the release of insulin that is reliant on glucose

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The GLP-1/GIP dual agonist tirzepatide effectively reduced tumor growth in both obese and lean mice, and improved obesity-associated serum adiponectin, leptin and C-reactive protein levels in obese mice (69)

Despite the very low absolute risk for ischemic optic neuropathy, the rapidly expanding use of GLP-1 receptor agonists in patients with and without type 2 diabetes increases the clinical and public health importance of any potential association, conclude the authors

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