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Una reciente revisin narrativa analiza los efectos del agonismo del receptor de incretina particularmente de los agonistas del receptor del pptido similar al glucagn tipo 1 (GLP-1RA) y de los agonistas duales de los receptores GLP-1 y GIP (GLP-1/GIPRA) sobre la masa libre de grasa (MLG) y la aptitud cardiorrespiratoria

hazard ratio 0.71, 0.52 to 0.98), whereas serious renal events generated a wide confidence interval (1.4 v 2.0 events per 1000 person years

Watch the discussion to learn how this broader approach could shape the next chapter of longevity science

More specifically, they were originally designed for people with non-insulin dependent diabetes

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While challenges with adherence, side effects, and weight regain upon discontinuation have prompted the search for additional strategies, targets like GLP-1R, GIPR, and GDF8 (Myostatin) still remain the most highly relevant and active areas of research for developing effective obesity treatments