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The day of weekly administration can be changed if needed as long as the time between 2 doses is at least 2 days (greater than 48 hours)

Minocycline is a tetracycline that was demonstrated to not only modulate the dopaminergic and glutamatergic CNS signaling but also to restore the physiologic Firmicutes/Bacteroidetes ratio in the gut with positive effect on hypertension (162)

Side effects for both injectable drugs are generally mild

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