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Bomba M, Granzotto A, Castelli V, et al

When Concurrent Use Requires Extra Caution or Alternative Approaches Patients with existing gastrointestinal disorders (gastroparesis, inflammatory bowel disease, severe reflux), those on high semaglutide doses, or those with chronic opioid dependency should discuss alternative pain management strategies with their providers
Arterioscler Thromb Vasc Biol (2012) 32:15139

Shubert emphasized in an email that Novo Nordisk is the only company in the US with FDA-approved medicines containing semaglutide. Unapproved compounded semaglutide drugs, she continued, do not have the same safety, quality, and effectiveness assurances as Novo Nordisks FDA-approved semaglutide medicines, and patients should not use a compounded drug if an approved drug is available. Where to next

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In addition, it has not been studied in patients with pancreatitis
