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Factors like: Perimenopause Menopause Insulin resistance Stress + cortisol can all impact how your body responds, even on medication

Studies on subdiaphragmatic vagal deafferentation, which spares approximately 50% of vagal afferent nerves, have also confirmed the roles of vagal afferent nerves in mediating the effects of GLP-1 [30, 31], as confirmed in a mouse model with GLP-1R knockdown in vagal afferent nerves [32]

At the same time, its important to note that this is an evolving area of research

Eating carbohydrates first is less effective

Extending these works further, DiMarchi and co-workers also developed a coagonist on GLP-1R and gastric inhibitory polypeptide (GIP) receptor to achieve a greater weight loss effect than GLP-1 alone

Prevention repairs the damage from accelerated aging