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PDE5 inhibitors constitute the first-line treatment, while adjunctive TRT may be considered for hypogonadal non-responders, with careful attention to potential side effects, such as gastrointestinal symptoms, increased blood pressure, and thrombosis [206]

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Hepatocyte cultures characterise effects on glucose output (where glucagon signalling raises and incretin signalling lowers), lipogenic gene expression, mitochondrial function, and lipid oxidation pathway activation

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