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ABSTRACT INTRODUCTION LIMITED EFFICACY OF METFORMIN AND SULFONYLUREA DURABILITY OF GLUCOSE CONTROL WITH THIAZOLIDINEDIONE EFFICACY AND SAFETY OF GLP-1 ANALOGS SUGGESTIVE EXTRA-ISLET ACTION OF DPP-IV INHIBITORS COMBINATION OF THIAZOLIDINEDIONE AND DPPIV INHIBITOR (Table 2) TRIPLE COMBINATION - METFORMIN, THIAZOLIDINEDIONE AND GLP-1 ANALOGS (Table 2) CONCLUSION REFERENCES About this article ABSTRACT Although there is no HbA1c threshold for cardiovascular risk, the American Diabetic Association-recommended goal of HbA1c 1.5 years), active-comparator or double-blind placebo-controlled studies with TZDs present a very different picture [6-8]

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Microbial Diversity: Certain bacterial genera (e.g., Akkermansia muciniphila , Bifidobacterium , and Lactobacillus ) have been shown to enhance GLP-1 activity and improve metabolic outcomes in animal and human studies

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