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Description
The reason is that drugs deliver synthetic appetite-suppressing chemical messengers like GLP-1, GIP, and glucagon agonists at levels astronomically higher than normally produced by the body

Parrott J, Frank L, Rabena R, Craggs-Dino L, Isom KA, Greiman L

In many cases, symptoms improve on their own within a few days without affecting ongoing treatment
[DOI] [PMC free article] [PubMed] [Google Scholar] 125.Jastreboff AM, Kaplan LM, Fras JP, et al
GLP-1 Receptor Agonists: an Updated Review of Head-To-Head Clinical Studies

Irs2 is a substrate of the IGF1 and insulin receptor tyrosine kinases that promote growth, function and survival of the -cells [547]