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Domperidone is a type II dopamine antagonist similar to metoclopramide, and is equally efficacious but with lower central side effects

Its purpose is to let your gastrointestinal system adjust to the dual GIP/GLP-1 receptor activation that tirzepatide produces

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The mechanism remains active as long as the medication is in your system, meaning interrupted or stopped therapy typically results in appetite normalization within weeks

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Potential Interactions Between Mounjaro and Local Anaesthetics No clinically significant pharmacological interactions are expected between tirzepatide (Mounjaro) and commonly used local anaesthetic agents, according to the Mounjaro Summary of Product Characteristics