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Gilbert D

10.1016/S0140-6736(21)01443-4 [DOI] [PubMed] 187.Del Prato S, Kahn SE, Pavo I et al (2021) Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial

thus, healthcare providers must be aware of these precautions, contraindications, and black box warnings

Semaglutide was associated with meaningful reductions in biological aging across seven of these system-specific measures, with the largest effects in clocks tracking inflammation, brain aging, and metabolic aging

5 This wide distribution of incretin hormone receptors may indicate important whole-body functions of these compounds

But should be used cautiously due to GI & heart risks, especially in chronic conditions