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After a lifetime of struggling with her weight and managing diabetes with multiple daily insulin

Clinical trials have shown that injectable GLP-1 agents generally produce slightly greater reductions in HbA1c

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Physiol Rev (2015) 95(2):51348

However, semaglutide has been the most extensively studied, with the largest number of clinical trials analyzed

A recent systematic review and network meta-analysis study, including nine RCTs, compared the effects of GLP-1RAs, pioglizatone, and vitamin E treatments [58]
