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Approximately 24% mean weight loss at highest dose (phase 2, NEJM 2023)

Estrogen decline leads to increased abdominal fat accumulation, decreased lean mass, and the development of insulin resistance

Based on Phase 2 trial data (Jastreboff et al., NEJM , 2023), diarrhoea was reported in a meaningful proportion of participants treated with retatrutide, with incidence increasing in a dose-dependent manner

Medical weight loss is generally safe when done under the supervision of professionals

We see these side effects for a few reasons: GLP-1s delay how fast our stomachs empty which can lead to bloating, fullness and nausea

Patients should be extremely cautious of any websites, social media advertisements, or online retailers claiming to sell GLP-1 patches