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Additionally, if CV risk was managed upstream through weight reduction, unmet need due to high residual CV risk would likely manifest itself in specific patient sub-segments and thus require innovators to take a highly targeted approach in both clinical development and commercialisation

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Method All individual case safety reports for semaglutide, liraglutide, and tirzepatide reported to the EudraVigilance database from 01/01/2021 to 30/05/2023 were analysed