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Peptides and Mast Cell Activation: How GLP-1, GLP-2 and VIP Support the Nervous System in MCAS By Reine DuBois, Integrative Naturopath and Clinical Director The Health Lodge Understanding MCAS and Nervous System Involvement Mast Cell Activation Syndrome (MCAS) is a complex inflammatory disorder in which mast cells release excessive histamine and other mediators, causing symptoms that can affect every organ system

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GIP receptor activation was historically thought to have limited therapeutic potential in type 2 diabetes, as the insulinotropic response to GIP is often impaired in affected individuals